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Agammaglobulinemia Alessandro Plebani
Publisher: Springer International Publishing

Immunoglobulins are a type of antibody. Bruton agammaglobulinemia (see the image below) was the first primary immunodeficiency disease to be described. Atypical X-linked agammaglobulinemia diagnosed in three adults. Low levels of these antibodies make you more likely to get infections. Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies. Agammaglobulinemia is a disorder passed down through families in which a person has very low levels of protective immune system proteins called immunoglobulins. X-linked agammaglobulinemia (XLA) has been described as a disorder in which pre-B cells fail to differentiate into B cells. The official name of this gene is “Bruton agammaglobulinemia tyrosine kinase.” BTK is the gene's official symbol. X-linked agammaglobulinemia (XLA) is a human antibody deficiency that results from mutation of the tyrosine kinase btk. X-linked agammaglobulinemia (XLA) is characterized by recurrent bacterial infections in affected males in the first two years of life. Pyoderma gangrenosum-like ulcer in a patient with X-linked agammaglobulinemia: identification of Helicobacter bilis by mass spectrometry analysis. Agammaglobulinemia is a group of inherited immune deficiencies characterized by a low concentration of antibodies in the blood due to the lack of particular lymphocytes in the blood and lymph. PMID: 14929630; [PubMed - indexed for MEDLINE]. The molecular basis for X-linked agammaglobulinemia, hyper-IgM syndrome, and severe combined immunodeficiency was recently identified. X-linked agammaglobulinemia (XLA) is a hereditary immunodeficiency caused by mutations in the gene encoding Bruton tyrosine kinase (BTK). Antibodies are proteins (immunoglobulins, (IgM), (IgG) etc) that are critical and key components of the immune system.